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set-15 SET domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187813, updated on 2-Nov-2024

Summary

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Official Symbol
set-15
Official Full Name
SET domain-containing protein
Primary source
WormBase:WBGene00020006
Locus tag
CELE_R11E3.4
See related
AllianceGenome:WB:WBGene00020006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone H3 methyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in chromatin. Is expressed in intestine and neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See set-15 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (4776364..4780229, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Solute carrier family 23 member 2 Neighboring gene ncRNA Neighboring gene TransThyretin-Related family domain Neighboring gene NR LBD domain-containing protein;Nuclear receptor domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans. Huang M, et al. Elife, 2022 Sep 20. PMID 36125117, Free PMC Article
  2. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Greer EL, et al. Nature, 2010 Jul 15. PMID 20555324, Free PMC Article
  3. Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development. Andersen EC, et al. Development, 2007 Aug. PMID 17634190
  4. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
  5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone H3 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SET domain-containing protein
NP_001370771.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4776364..4780229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383087.1 → NP_001370771.1  SET domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TYX6
    Conserved Domains (1) summary
    smart00317
    Location:405 → 554
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
Nucleotide Protein
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