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icpp-55 Aminopeptidase P N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187899, updated on 2-Nov-2024

Summary

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Official Symbol
icpp-55
Official Full Name
Aminopeptidase P N-terminal domain-containing protein
Primary source
WormBase:WBGene00020088
Locus tag
CELE_R119.2
See related
AllianceGenome:WB:WBGene00020088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nephronophthisis-like nephropathy 1. Orthologous to human XPNPEP3 (X-prolyl aminopeptidase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See icpp-55 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (368270..373465, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene pseudo Neighboring gene RRM domain-containing protein Neighboring gene DeHydrogenases, Short chain Neighboring gene Prion-like (glutamine/asparagine-rich) domain bearing protein pqn-59 Neighboring gene Transcription initiation factor TFIID subunit 4 Neighboring gene Protein-L-isoaspartate O-methyltransferase domain-containing protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Aminopeptidase P N-terminal domain-containing protein
NP_001417605.1
  • Confirmed by transcript evidence
NP_490725.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    368270..373465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058324.5 → NP_490725.3  Aminopeptidase P N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490725.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61710
    Conserved Domains (2) summary
    pfam05195
    Location:20 → 149
    AMP_N; Aminopeptidase P, N-terminal domain
    cl00279
    Location:188 → 427
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

  2. NM_001430679.1 → NP_001417605.1  Aminopeptidase P N-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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