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Prl2c3 prolactin family 2, subfamily c, member 3 [ Mus musculus (house mouse) ]

Gene ID: 18812, updated on 2-Nov-2024

Summary

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Official Symbol
Prl2c3provided by MGI
Official Full Name
prolactin family 2, subfamily c, member 3provided by MGI
Primary source
MGI:MGI:1341833
See related
Ensembl:ENSMUSG00000056457 AllianceGenome:MGI:1341833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ghd1; Plf2; MRP-2; MRP-3; PLF-2; PLF-3; Prl2c4; Mrpplf3; mrp/plf3
Summary
Enables growth factor activity and hormone activity. Acts upstream of or within positive regulation of hematopoietic stem cell proliferation. Located in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward placenta adult (RPKM 2865.0) See more
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Genomic context

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See Prl2c3 in Genome Data Viewer
Location:
13; 13 A1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (12805705..12814982, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (12790816..12800093, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nidogen-1-like Neighboring gene STARR-positive B cell enhancer ABC_E7202 Neighboring gene NHP2-like protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr13:12896090-12896390 Neighboring gene STARR-seq mESC enhancer starr_33671 Neighboring gene STARR-positive B cell enhancer mm9_chr13:12913866-12914166 Neighboring gene predicted gene, 53256 Neighboring gene STARR-positive B cell enhancer mm9_chr13:12918988-12919289 Neighboring gene R3H domain containing 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells. Choong ML, et al. FEBS Lett, 2003 Aug 28. PMID 12935903
  2. Characterization of a mouse mitogen-regulated protein/proliferin gene and its promoter: a member of the growth hormone/prolactin gene superfamily. Connor AM, et al. Biochim Biophys Acta, 1989 Sep 21. PMID 2790033
  3. Identification of proliferin mRNA and protein in mouse placenta. Linzer DI, et al. Proc Natl Acad Sci U S A, 1985 Jul. PMID 3859868, Free PMC Article
  4. Proliferin enhances microvilli formation and cell growth of neuroblastoma cells. Wang JW, et al. Neurosci Res, 2006 Sep. PMID 16876275
  5. The mouse prolactin gene family locus. Wiemers DO, et al. Endocrinology, 2003 Jan. PMID 12488360

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hormone activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
prolactin-2C3
Names
growth hormone d1
mitogen-regulated protein 2
mitogen-regulated protein 3
prolactin-2C4
proliferin-2
proliferin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011118.2 → NP_035248.2  prolactin-2C3 precursor

    See identical proteins and their annotated locations for NP_035248.2

    Status: VALIDATED

    Source sequence(s)
    AK164068, BU755317
    Consensus CDS
    CCDS36595.1
    UniProtKB/Swiss-Prot
    P04768, P18918, Q498A5, Q6PDB6
    UniProtKB/TrEMBL
    A0A0M5HDY5, Q6P215, Q7TND2
    Related
    ENSMUSP00000097393.2, ENSMUST00000099805.3
    Conserved Domains (1) summary
    pfam00103
    Location:33 → 224
    Hormone_1; Somatotropin hormone family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    12805705..12814982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516579.1 → XP_006516642.1  prolactin-2C3 isoform X2

    UniProtKB/TrEMBL
    Q7TND2
    Conserved Domains (1) summary
    cl07831
    Location:24 → 188
    growth_hormone_like; Somatotropin/prolactin hormone family

  2. XM_006516578.4 → XP_006516641.1  prolactin-2C3 isoform X1

    UniProtKB/TrEMBL
    Q6P215, Q7TND2
    Conserved Domains (1) summary
    pfam00103
    Location:22 → 222
    Hormone_1; Somatotropin hormone family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04768.2 GenPept UniProtKB/Swiss-Prot:P04768

Gene LinkOut

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