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nas-20 Zinc metalloproteinase nas-20 [ Caenorhabditis elegans ]

Gene ID: 188420, updated on 18-Sep-2024

Summary

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Official Symbol
nas-20
Official Full Name
Zinc metalloproteinase nas-20
Primary source
WormBase:WBGene00003539
Locus tag
CELE_T11F9.3
See related
AllianceGenome:WB:WBGene00003539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in molting cycle and proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nas-20 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (11470925..11472309, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Zrt (ZRT), Irt- (IRT-) like Protein Transporter Neighboring gene ncRNA Neighboring gene Amino acid transporter protein 6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase-like protein nas-21 Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-22

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Golden TR, et al. Aging Cell, 2008 Dec. PMID 18778409, Free PMC Article
  2. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in molting cycle, collagen and cuticulin-based cuticle IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc metalloproteinase nas-20
NP_505906.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11470925..11472309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073505.9 → NP_505906.2  Zinc metalloproteinase nas-20 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505906.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22396, Q7Z0M9
    Conserved Domains (2) summary
    pfam01400
    Location:36 → 209
    Astacin; Astacin (Peptidase family M12A)
    cl00064
    Location:49 → 205
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22396.2

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