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aex-4 t-SNARE protein aex-4 [ Caenorhabditis elegans ]

Gene ID: 188509, updated on 2-Nov-2024

Summary

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Official Symbol
aex-4
Official Full Name
t-SNARE protein aex-4
Primary source
WormBase:WBGene00006454
Locus tag
CELE_T14G12.2
See related
AllianceGenome:WB:WBGene00006454
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in positive regulation of defecation and positive regulation of protein secretion. Located in plasma membrane. Is expressed in intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aex-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (3729281..3731961)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-like protein 1 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Forkhead box protein fkh-2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans. Lin-Moore AT, et al. PLoS Genet, 2021 Nov. PMID 34818334, Free PMC Article
  2. PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C. elegans neurons. Zhou KM, et al. Neuron, 2007 Nov 21. PMID 18031683
  3. Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans. Mahoney TR, et al. Proc Natl Acad Sci U S A, 2008 Oct 21. PMID 18852466, Free PMC Article
  4. Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions. Didiano D, et al. Nat Struct Mol Biol, 2006 Sep. PMID 16921378
  5. Reversal of a muscle response to GABA during C. elegans male development. Reiner DJ, et al. J Neurosci, 1995 Sep. PMID 7666193, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of defecation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of defecation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
t-SNARE protein aex-4
NP_508641.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3729281..3731961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076240.8 → NP_508641.2  t-SNARE protein aex-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508641.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEN8
    Conserved Domains (1) summary
    cl22856
    Location:173 → 231
    SNARE; SNARE motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EEN8.1

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