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inx-10 Innexin;Innexin-10 [ Caenorhabditis elegans ]

Gene ID: 188580, updated on 2-Nov-2024

Summary

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Official Symbol
inx-10
Official Full Name
Innexin;Innexin-10
Primary source
WormBase:WBGene00002132
Locus tag
CELE_T18H9.5
See related
AllianceGenome:WB:WBGene00002132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable gap junction hemi-channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in gap junction. Is expressed in several structures, including hermaphrodite gonad; neurons; pharynx; rectal epithelium; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See inx-10 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (9204661..9207477, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene pseudo Neighboring gene Peptidase A1 domain-containing protein Neighboring gene MeDiaTor Neighboring gene Phosphofurin acidic cluster sorting protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Six innexins contribute to electrical coupling of C. elegans body-wall muscle. Liu P, et al. PLoS One, 2013. PMID 24130800, Free PMC Article
  2. High-Throughput All-Optical Analysis of Synaptic Transmission and Synaptic Vesicle Recycling in Caenorhabditis elegans. Wabnig S, et al. PLoS One, 2015. PMID 26312752, Free PMC Article
  3. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Guan L, et al. Traffic, 2022 Mar. PMID 34994051
  4. Presynaptic coupling by electrical synapses coordinates a rhythmic behavior by synchronizing the activities of a neuron pair. Choi U, et al. Proc Natl Acad Sci U S A, 2021 May 18. PMID 33972428, Free PMC Article
  5. The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. Barnes TM, et al. J Neurochem, 1997 Dec. PMID 9375655

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gap junction channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables gap junction hemi-channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in gap junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in gap junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in gap junction IEA
Inferred from Electronic Annotation
more info
  
located_in gap junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Innexin;Innexin-10
NP_001024139.1
  • Confirmed by transcript evidence
NP_001024140.1
  • Partially confirmed by transcript evidence
NP_001360570.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9204661..9207477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373070.2 → NP_001360570.1  Innexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WYM8, T2DJN8
    Conserved Domains (1) summary
    pfam00876
    Location:20 → 379
    Innexin

  2. NM_001028969.6 → NP_001024140.1  Innexin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024140.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AHN7, T2DJN8
    Conserved Domains (1) summary
    pfam00876
    Location:20 → 380
    Innexin; Innexin

  3. NM_001028968.4 → NP_001024139.1  Innexin-10 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024139.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22549
    UniProtKB/TrEMBL
    T2DJN8
    Conserved Domains (1) summary
    pfam00876
    Location:20 → 380
    Innexin; Innexin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22549.1

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