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ctf-8 Ctf8 [ Caenorhabditis elegans ]

Gene ID: 188728, updated on 2-Nov-2024

Summary

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Official Symbol
ctf-8
Official Full Name
Ctf8
Primary source
WormBase:WBGene00011915
Locus tag
CELE_T22C1.4
See related
AllianceGenome:WB:WBGene00011915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity. Predicted to be involved in mitotic sister chromatid cohesion. Predicted to be located in nucleus. Predicted to be part of Ctf18 RFC-like complex. Orthologous to human CHTF8 (chromosome transmission fidelity factor 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ctf-8 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (7940134..7940728, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Myosin-11 Neighboring gene UBR-type domain-containing protein Neighboring gene Globin-like protein 26 Neighboring gene GPI transamidase component GAB1 Neighboring gene TFIIIC_sub6 domain-containing protein Neighboring gene Transport and Golgi organization protein 1 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target. McLellan J, et al. Mol Biol Cell, 2009 Dec. PMID 19846659, Free PMC Article
  2. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ctf18 RFC-like complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ctf8
NP_492190.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7940134..7940728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059789.6 → NP_492190.2  Ctf8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492190.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22664
    Conserved Domains (1) summary
    pfam09696
    Location:48 → 105
    Ctf8; Ctf8
Nucleotide Protein
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