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vab-9 Transmembrane protein 47 [ Caenorhabditis elegans ]

Gene ID: 188736, updated on 2-Nov-2024

Summary

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Official Symbol
vab-9
Official Full Name
Transmembrane protein 47
Primary source
WormBase:WBGene00006875
Locus tag
CELE_T22C8.8
See related
AllianceGenome:WB:WBGene00006875
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in cell-cell adhesion; defense response to Gram-negative bacterium; and innate immune response. Located in cell junction. Is expressed in epithelial cell; hypodermis; and nerve ring. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to several human genes including TMEM47 (transmembrane protein 47). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vab-9 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (8636233..8637715, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Specificity protein transcription factor 2 Neighboring gene Ntox44 domain-containing protein Neighboring gene ZP domain-containing protein Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Integrase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vertebrate Claudin/PMP22/EMP22/MP20 family protein TMEM47 regulates epithelial cell junction maturation and morphogenesis. Dong Y, et al. Dev Dyn, 2016 Jun. PMID 26990309, Free PMC Article
  2. Claudins reign: The claudin/EMP/PMP22/γ channel protein family in C. elegans. Simske JS. Tissue Barriers, 2013 Jul 1. PMID 24665403, Free PMC Article
  3. The origin of footprints of the Tc1 transposon of Caenorhabditis elegans. Plasterk RH. EMBO J, 1991 Jul. PMID 1646714, Free PMC Article
  4. The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Simske JS, et al. Nat Cell Biol, 2003 Jul. PMID 12819787
  5. The C. elegans zonula occludens ortholog cooperates with the cadherin complex to recruit actin during morphogenesis. Lockwood C, et al. Curr Biol, 2008 Sep 9. PMID 18718757, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transmembrane protein 47
NP_495836.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8636233..8637715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063435.5 → NP_495836.2  Transmembrane protein 47 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495836.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED30
    Conserved Domains (1) summary
    cl21598
    Location:23 → 185
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein
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