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cfi-1 AT-rich interactive domain-containing protein cfi-1 [ Caenorhabditis elegans ]

Gene ID: 188793, updated on 2-Nov-2024

Summary

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Official Symbol
cfi-1
Official Full Name
AT-rich interactive domain-containing protein cfi-1
Primary source
WormBase:WBGene00000476
Locus tag
CELE_T23D8.8
See related
AllianceGenome:WB:WBGene00000476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; neuron fate specification; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in head muscle; neurons; and pharyngeal muscle cell. Orthologous to several human genes including ARID3B (AT-rich interaction domain 3B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cfi-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (9993906..9999928, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein argonaute-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protocol for auxin-inducible protein degradation in C. elegans using different auxins and TIR1-expressing strains. Sharma N, et al. STAR Protoc, 2024 Sep 20. PMID 38878287, Free PMC Article
  2. Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation. Li Y, et al. Cell Rep, 2023 Mar 28. PMID 36897776, Free PMC Article
  3. The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types. Zhang F, et al. Development, 2014 Jan. PMID 24353061, Free PMC Article
  4. The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons. Berghoff EG, et al. Elife, 2021 Jun 24. PMID 34165428, Free PMC Article
  5. Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression. Kerk SY, et al. Neuron, 2017 Jan 4. PMID 28056346, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation.
    Title: Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AT-rich interactive domain-containing protein cfi-1
NP_492644.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9993906..9999928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060243.4 → NP_492644.2  AT-rich interactive domain-containing protein cfi-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492644.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02326, Q8T628
    Conserved Domains (1) summary
    smart01014
    Location:183 → 269
    ARID; ARID/BRIGHT DNA binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02326.3

Gene LinkOut

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