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clc-19 Transmembrane protein 225 [ Caenorhabditis elegans ]

Gene ID: 188845, updated on 2-Nov-2024

Summary

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Official Symbol
clc-19
Official Full Name
Transmembrane protein 225
Primary source
WormBase:WBGene00020760
Locus tag
CELE_T24C4.4
See related
AllianceGenome:WB:WBGene00020760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in innate immune response. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clc-19 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (872621..873566, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ZSWIM3 N-terminal domain-containing protein Neighboring gene Protein DPCD Neighboring gene DUF2975 domain-containing protein Neighboring gene DNA primase Neighboring gene Peptidase M16 N-terminal domain-containing protein Neighboring gene Zyg eleven-related protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Irazoqui JE, et al. Proc Natl Acad Sci U S A, 2008 Nov 11. PMID 18981407, Free PMC Article
  2. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. Troemel ER, et al. PLoS Genet, 2006 Nov 10. PMID 17096597, Free PMC Article
  3. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in innate immune response HEP PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transmembrane protein 225
NP_497282.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    872621..873566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064881.8 → NP_497282.2  Transmembrane protein 225 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497282.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TZ35
    Conserved Domains (1) summary
    pfam06653
    Location:78 → 155
    Claudin_3; Tight junction protein, Claudin-like
Nucleotide Protein
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