lgc-40 Ligand-Gated ion Channel [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lgc-40
Official Full Name: Ligand-Gated ion Channel
Primary source: WormBase:WBGene00020767
Locus tag: CELE_T24D8.1
See related: AllianceGenome:WB:WBGene00020767
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lgc-40 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (2360126..2364822)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study identified 3 ligand-gated chloride channels that are receptors for biogenic amines: LGC-53 is a high-affinity dopamine receptor, LGC-55 is a high-affinity tyramine receptor & LGC-40 is a low-affinity serotonin receptor
Title: Ligand-gated chloride channels are receptors for biogenic amines in C. elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T24D8.1 (e-PCR)
- UniSTS:315088

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ligand-Gated ion Channel

NP_001407535.1

Confirmed by transcript evidence

NP_001407536.1

Confirmed by transcript evidence

NP_001407537.1

Confirmed by transcript evidence

NP_508428.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2360126..2364822

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076027.9 → NP_508428.2 Ligand-Gated ion Channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508428.2

Status: REVIEWED

UniProtKB/TrEMBL

Q22741

Conserved Domains (3) summary

TIGR00860
Location:9 → 490

LIC; Cation transporter family protein

pfam02931
Location:44 → 242

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:249 → 487

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001420568.1 → NP_001407535.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4SRX7
NM_001420567.1 → NP_001407536.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4SQM5
NM_001420569.1 → NP_001407537.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4SS69