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clec-38 C-type lectin domain-containing protein 38 [ Caenorhabditis elegans ]

Gene ID: 188900, updated on 2-Nov-2024

Summary

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Official Symbol
clec-38
Official Full Name
C-type lectin domain-containing protein 38
Primary source
WormBase:WBGene00012025
Locus tag
CELE_T25E12.10
See related
AllianceGenome:WB:WBGene00012025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carbohydrate binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and synaptic vesicle localization. Predicted to be located in membrane. Is expressed in PLML; PLMR; head neurons; intestine; and ventral cord neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clec-38 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (16733821..16735618, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class Z Neighboring gene Uncharacterized protein Neighboring gene C-type lectin domain-containing protein Neighboring gene C-type lectin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The roles of multiple UNC-40 (DCC) receptor-mediated signals in determining neuronal asymmetry induced by the UNC-6 (netrin) ligand. Xu Z, et al. Genetics, 2009 Nov. PMID 19704011, Free PMC Article
  2. CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40-mediated axon outgrowth and promotes presynaptic development in Caenorhabditis elegans. Kulkarni G, et al. J Neurosci, 2008 Apr 23. PMID 18434533, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLEC-38 plays a role in promoting synapse assembly and refining axon outgrowth activity.
    Title: CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40-mediated axon outgrowth and promotes presynaptic development in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dorsal/ventral axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in motor neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of axon extension involved in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of sensory neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of sensory neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dorsal/ventral axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of motor neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of sensory neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in synaptic vesicle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-type lectin domain-containing protein 38
NP_507233.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16733821..16735618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074832.4 → NP_507233.2  C-type lectin domain-containing protein 38 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507233.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45824
    Conserved Domains (1) summary
    smart00034
    Location:122 → 250
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
Nucleotide Protein
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