asic-2 Degenerin-like protein asic-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: asic-2
Official Full Name: Degenerin-like protein asic-2
Primary source: WormBase:WBGene00012137
Locus tag: CELE_T28F4.2
See related: AllianceGenome:WB:WBGene00012137
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in ciliated neurons and sensory neurons. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 2; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1A (sodium channel epithelial 1 subunit alpha); SCNN1B (sodium channel epithelial 1 subunit beta); and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See asic-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (7480108..7483505)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The channel subunit MEC-4 is specifically required for neural responses to gentle mechanical stimulation but does not affect the basic physiology of touch neurons.
Title: In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-246 (e-PCR)
- UniSTS:241738

T28F4.2 (e-PCR)
- UniSTS:315127

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Degenerin-like protein asic-2

NP_492099.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7480108..7483505

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059698.3 → NP_492099.1 Degenerin-like protein asic-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492099.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22851

Conserved Domains (2) summary

TIGR00867
Location:12 → 474

deg-1; degenerin

pfam00858
Location:13 → 471

ASC; Amiloride-sensitive sodium channel