ndx-2 Putative nudix hydrolase 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ndx-2
Official Full Name: Putative nudix hydrolase 2
Primary source: WormBase:WBGene00003579
Locus tag: CELE_W02G9.1
See related: AllianceGenome:WB:WBGene00003579
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ADP-ribose diphosphatase activity. Predicted to be involved in nucleoside phosphate metabolic process and ribose phosphate metabolic process. Predicted to be active in nucleus. Orthologous to human NUDT5 (nudix hydrolase 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ndx-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (2662964..2665003, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NDX-2 hydrolyzes 8-oxo-dGDP to 8-oxo-dGMP.
Title: An increase of oxidised nucleotides activates DNA damage checkpoint pathway that regulates post-embryonic development in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W02G9.1 (e-PCR)
- UniSTS:319698

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ADP-ribose diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pyrophosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nucleoside phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribose phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Putative nudix hydrolase 2

NP_503726.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

2662964..2665003 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071325.6 → NP_503726.1 Putative nudix hydrolase 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503726.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61902

Conserved Domains (1) summary

cd03424
Location:75 → 221

ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...