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gpa-18 G Protein, Alpha subunit [ Caenorhabditis elegans ]

Gene ID: 189161, updated on 2-Nov-2024

Summary

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Official Symbol
gpa-18
Official Full Name
G Protein, Alpha subunit
Primary source
WormBase:WBGene00020997
Locus tag
CELE_W03F8.9
See related
AllianceGenome:WB:WBGene00020997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-activating dopamine receptor signaling pathway and sensory perception of chemical stimulus. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in neurons; tail; and in male. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gpa-18 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (5189007..5195631, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene EKC/KEOPS complex subunit TPRKB Neighboring gene Activin_recp domain-containing protein;DUF3309 domain-containing protein;Secreted protein Neighboring gene Peptide chain release factor 1;putative peptide chain release factor 1, mitochondrial Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of chemical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G Protein, Alpha subunit
NP_001293718.1
  • Product from WormBase gene class gpa;
    Confirmed by transcript evidence
NP_001293719.1
  • Product from WormBase gene class gpa;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5189007..5195631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306790.3 → NP_001293719.1  G Protein, Alpha subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293719.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLB7
    Conserved Domains (1) summary
    pfam00503
    Location:8 → 309
    G-alpha; G-protein alpha subunit

  2. NM_001306789.3 → NP_001293718.1  G Protein, Alpha subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293718.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLF3
    Conserved Domains (1) summary
    pfam00503
    Location:8 → 307
    G-alpha; G-protein alpha subunit
Nucleotide Protein
Heading Accession and Version

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