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sms-5 Sphingomyelin synthase-related 2 [ Caenorhabditis elegans ]

Gene ID: 189276, updated on 2-Nov-2024

Summary

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Official Symbol
sms-5
Official Full Name
Sphingomyelin synthase-related 2
Primary source
WormBase:WBGene00021075
Locus tag
CELE_W07E6.3
See related
AllianceGenome:WB:WBGene00021075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Is expressed in pharynx and spermatheca. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sms-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (495424..498757)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene NLE domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class H

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The marginal cells of the Caenorhabditis elegans pharynx scavenge cholesterol and other hydrophobic small molecules. Kamal M, et al. Nat Commun, 2019 Sep 2. PMID 31477732, Free PMC Article
  2. PGP-14 establishes a polar lipid permeability barrier within the C. elegans pharyngeal cuticle. Kamal M, et al. PLoS Genet, 2023 Nov. PMID 37930961, Free PMC Article
  3. Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways. He B, et al. PLoS Genet, 2021 May. PMID 34014977, Free PMC Article
  4. The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C. elegans. Galford KF, et al. Chemosphere, 2020 Dec. PMID 32731027, Free PMC Article
  5. Sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of Caenorhabditis elegans. Luo H, et al. J Lipid Res, 2024 Jun. PMID 38704027, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ceramide cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingomyelin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingomyelin biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sphingomyelin synthase-related 2
NP_001293556.1
  • Confirmed by transcript evidence
NP_001293557.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    495424..498757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306627.2 → NP_001293556.1  Sphingomyelin synthase-related 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293556.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9TYV2, U4PB50, U4PED8
    Conserved Domains (1) summary
    pfam14360
    Location:192 → 265
    PAP2_C; PAP2 superfamily C-terminal

  2. NM_001306628.3 → NP_001293557.1  Sphingomyelin synthase-related 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293557.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PB50
    Conserved Domains (1) summary
    pfam14360
    Location:86 → 159
    PAP2_C; PAP2 superfamily C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TYV2.2

Gene LinkOut

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