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lagr-1 putative ceramide synthase lagr-1 [ Caenorhabditis elegans ]

Gene ID: 189370, updated on 2-Nov-2024

Summary

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Official Symbol
lagr-1
Official Full Name
putative ceramide synthase lagr-1
Primary source
WormBase:WBGene00006505
Locus tag
CELE_Y6B3B.10
See related
AllianceGenome:WB:WBGene00006505
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to be located in membrane. Is expressed in pharynx. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 8. Orthologous to human CERS1 (ceramide synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lagr-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (13724577..13732046, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein;TRAM domain-containing protein Neighboring gene Activin_recp domain-containing protein Neighboring gene inositol-phosphate phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition. Zhu H, et al. J Biol Chem, 2024 Jun. PMID 38677510, Free PMC Article
  2. Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans. Mosbech MB, et al. PLoS One, 2013. PMID 23894595, Free PMC Article
  3. C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. van Ham TJ, et al. PLoS Genet, 2008 Mar 21. PMID 18369446, Free PMC Article
  4. Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans. Pandey T, et al. Exp Gerontol, 2019 Jun. PMID 30825547
  5. Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1. Sharma S, et al. Mol Neurobiol, 2021 Jan. PMID 32894501

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables sphingosine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingosine N-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative ceramide synthase lagr-1
NP_493403.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13724577..13732046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061002.4 → NP_493403.1  putative ceramide synthase lagr-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493403.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XWE9
    Conserved Domains (1) summary
    smart00724
    Location:102 → 320
    TLC; TRAM, LAG1 and CLN8 homology domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XWE9.1

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