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vps-4 vesicle-fusing ATPase [ Caenorhabditis elegans ]

Gene ID: 189590, updated on 2-Nov-2024

Summary

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Official Symbol
vps-4
Official Full Name
vesicle-fusing ATPase
Primary source
WormBase:WBGene00021334
Locus tag
CELE_Y34D9A.10
See related
AllianceGenome:WB:WBGene00021334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP hydrolysis activity. Involved in mechanosensory behavior and protein localization to postsynaptic membrane. Predicted to be located in endosome membrane. Orthologous to human VPS4A (vacuolar protein sorting 4 homolog A) and VPS4B (vacuolar protein sorting 4 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vps-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (1053894..1066899, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PSP domain-containing protein;PSP proline-rich domain-containing protein Neighboring gene Glutaredoxin-1 Neighboring gene Conserved plasma membrane protein;Low-density lipoprotein receptor domain class A;Transmembrane protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Guanine nucleotide-binding protein G(s) subunit alpha Neighboring gene Uncharacterized protein Neighboring gene Autophagy-related protein 9;RGS domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans. Chun DK, et al. Mol Biol Cell, 2008 Jul. PMID 18434599, Free PMC Article
  2. Dominant-negative VPS-4 disrupts ODR-10::GFP distribution but has limited effects on chemotaxis. Zocher E, et al. MicroPubl Biol, 2018 Aug 2. PMID 32550384, Free PMC Article
  3. The ESCRT-III protein CeVPS-32 is enriched in domains distinct from CeVPS-27 and CeVPS-23 at the endosomal membrane of epithelial cells. Michelet X, et al. Biol Cell, 2009 Jul 31. PMID 19432559
  4. The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules. Matsushita-Ishiodori Y, et al. Biochem Biophys Res Commun, 2007 Jul 20. PMID 17531954
  5. Induction of autophagy in ESCRT mutants is an adaptive response for cell survival in C. elegans. Djeddi A, et al. J Cell Sci, 2012 Feb 1. PMID 22389403

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vesicle-fusing ATPase
NP_490816.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1053894..1066899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058415.9 → NP_490816.4  vesicle-fusing ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490816.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL83
    Conserved Domains (5) summary
    smart00382
    Location:150 → 286
    AAA; ATPases associated with a variety of cellular activities
    cd02678
    Location:4 → 79
    MIT_VPS4; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.
    pfam00004
    Location:154 → 284
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:365 → 425
    Vps4_C; Vps4 C terminal oligomerization domain
    cl21455
    Location:117 → 185
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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