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Y41C4A.32 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 189814, updated on 2-Nov-2024

Summary

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Official Symbol
Y41C4A.32
Official Full Name
WD_REPEATS_REGION domain-containing protein
Primary source
WormBase:WBGene00270321
Locus tag
CELE_Y41C4A.32
See related
AllianceGenome:WB:WBGene00270321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in Golgi vesicle transport and intracellular protein transport. Predicted to be located in COPI-coated vesicle membrane and Golgi apparatus. Predicted to be part of COPI vesicle coat. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Orthologous to human COPB2 (COPI coat complex subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y41C4A.32 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (11721706..11723607)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ubiquitin-like domain-containing protein Neighboring gene LITAF domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Exocyst complex component Sec10 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Cordeiro Rodrigues RJ, et al. Genes Dev, 2019 Jul 1. PMID 31147388, Free PMC Article
  2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in COPI-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WD_REPEATS_REGION domain-containing protein
NP_499518.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11721706..11723607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067117.5 → NP_499518.2  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1D3PDA8
    Conserved Domains (2) summary
    cd00200
    Location:8 → 271
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:17 → 52
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
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