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aakg-3 CBS domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 189836, updated on 2-Nov-2024

Summary

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Official Symbol
aakg-3
Official Full Name
CBS domain-containing protein
Primary source
WormBase:WBGene00021527
Locus tag
CELE_Y41G9A.3
See related
AllianceGenome:WB:WBGene00021527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in alimentary muscle; body wall musculature; head neurons; spermatheca; and ventral nerve cord. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1); PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2); and PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aakg-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (2976448..2981027)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 3 profile domain-containing protein;Gamma-aminobutyric acid type B receptor subunit 1 Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein Neighboring gene Intraflagellar transport protein 88 homolog Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allosteric regulation of C. elegans AMP-activated protein kinase. Scanlon DM, et al. MicroPubl Biol, 2022. PMID 35622498, Free PMC Article
  2. DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. Tullet JM, et al. PLoS Genet, 2014 Feb. PMID 24516399, Free PMC Article
  3. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of carbon utilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CBS domain-containing protein
NP_508509.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2976448..2981027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076108.7 → NP_508509.3  CBS domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508509.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N501
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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