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Y42H9AR.2 Protein lifeguard 2 [ Caenorhabditis elegans ]

Gene ID: 189842, updated on 2-Nov-2024

Summary

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Official Symbol
Y42H9AR.2
Official Full Name
Protein lifeguard 2
Primary source
WormBase:WBGene00021537
Locus tag
CELE_Y42H9AR.2
See related
AllianceGenome:WB:WBGene00021537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium channel activity. Predicted to be involved in apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of neuron apoptotic process. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1) and TMBIM1 (transmembrane BAX inhibitor motif containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y42H9AR.2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (8099901..8101476)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Fibronectin type-III domain-containing protein;Neuroglian Neighboring gene Transcription factor nsy-7 Neighboring gene ncRNA Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene FYVE-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein lifeguard 2
NP_501350.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8099901..8101476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068949.5 → NP_501350.3  Protein lifeguard 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501350.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4S1R3, Q9N3Y5
    Conserved Domains (1) summary
    cd10428
    Location:33 → 255
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
Nucleotide Protein
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