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tbx-37 T-box protein 37 [ Caenorhabditis elegans ]

Gene ID: 189977, updated on 2-Nov-2024

Summary

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Official Symbol
tbx-37
Official Full Name
T-box protein 37
Primary source
WormBase:WBGene00006556
Locus tag
CELE_Y47D3A.12
See related
AllianceGenome:WB:WBGene00006556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pharynx development. Located in nucleus. Is expressed in several structures, including ABalaa; ABalap; ABalpa; ABalpp; and ABaraa. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; bone disease (multiple); and cleft palate (multiple). Orthologous to several human genes including MGA (MAX dimerization protein MGA); TBX15 (T-box transcription factor 15); and TBX22 (T-box transcription factor 22). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tbx-37 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (11224808..11227125, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ABC transporter domain-containing protein Neighboring gene DUF4349 domain-containing protein Neighboring gene Elongation of very long chain fatty acids protein;Very-long-chain 3-oxoacyl-CoA synthase Neighboring gene AcidPPc domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo. Rumley JD, et al. Dev Biol, 2022 Sep. PMID 35660370, Free PMC Article
  2. The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos. Good K, et al. Development, 2004 May. PMID 15056620
  3. Early embryonic programming of neuronal left/right asymmetry in C. elegans. Poole RJ, et al. Curr Biol, 2006 Dec 5. PMID 17141609
  4. Role of T-box gene tbx-2 for anterior foregut muscle development in C. elegans. Smith PA, et al. Dev Biol, 2007 Feb 1. PMID 17005176, Free PMC Article
  5. The conserved role and divergent regulation of foxa, a pan-eumetazoan developmental regulatory gene. de-Leon SB. Dev Biol, 2011 Sep 1. PMID 21130759, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that TBX-37 and TBX-38 play a key role in distinguishing the outcomes of two sequential Glp-1/Notch-mediated interactions.
    Title: The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in developmental process IEA
Inferred from Electronic Annotation
more info
  
involved_in pharynx development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-box protein 37
NP_499444.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11224808..11227125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067043.6 → NP_499444.2  T-box protein 37 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499444.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U2C9
    Conserved Domains (1) summary
    cd00182
    Location:9 → 199
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U2C9.2

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