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csp-3 Non-catalytic caspase homolog csp-3 [ Caenorhabditis elegans ]

Gene ID: 190006, updated on 2-Nov-2024

Summary

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Official Symbol
csp-3
Official Full Name
Non-catalytic caspase homolog csp-3
Primary source
WormBase:WBGene00000821
Locus tag
CELE_Y47H9C.6
See related
AllianceGenome:WB:WBGene00000821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables caspase binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and zymogen binding activity. Involved in positive regulation of behavior; positive regulation of embryonic development; and regulation of apoptotic process. Located in cytoplasm. Is expressed in several structures, including germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See csp-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (11888501..11890558, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DnaJ homolog subfamily C member 10;Thioredoxin domain-containing protein Neighboring gene ncRNA Neighboring gene Translation initiation factor eIF2B subunit beta Neighboring gene NACHT_N domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caspase protocols in Caenorhabditis elegans. Lee ES, et al. Methods Mol Biol, 2014. PMID 24567097
  2. Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Geng X, et al. Nat Struct Mol Biol, 2008 Oct. PMID 18776901, Free PMC Article
  3. Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades. Shaham S. J Biol Chem, 1998 Dec 25. PMID 9857046
  4. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Geng X, et al. Cell Death Differ, 2009 Oct. PMID 19575016, Free PMC Article
  5. Caspases: an ancient cellular sword of Damocles. Boyce M, et al. Cell Death Differ, 2004 Jan. PMID 14647235

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables caspase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zymogen binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in inhibition of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process involved in development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Non-catalytic caspase homolog csp-3
NP_493011.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    11888501..11890558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060610.4 → NP_493011.2  Non-catalytic caspase homolog csp-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493011.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECW5
    Conserved Domains (1) summary
    cl00042
    Location:11 → 132
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RNA

  1. NR_138525.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ECW5.1

Gene LinkOut

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Molecular Biology Databases
Research Materials