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S1PR3 sphingosine-1-phosphate receptor 3 [ Homo sapiens (human) ]

Gene ID: 1903, updated on 2-Nov-2024

Summary

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Official Symbol
S1PR3provided by HGNC
Official Full Name
sphingosine-1-phosphate receptor 3provided by HGNC
Primary source
HGNC:HGNC:3167
See related
Ensembl:ENSG00000213694 MIM:601965; AllianceGenome:HGNC:3167
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG3; LPB3; S1P3; EDG-3; C9orf47; C9orf108; bA791O21.3
Summary
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 15.3), esophagus (RPKM 10.2) and 24 other tissues See more
Orthologs
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Genomic context

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See S1PR3 in Genome Data Viewer
Location:
9q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (88990863..89005155)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (101153351..101167644)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91605778..91620070)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902205 Neighboring gene Sharpr-MPRA regulatory region 12308 Neighboring gene Sharpr-MPRA regulatory region 209 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91613461-91613962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91613963-91614462 Neighboring gene uncharacterized LOC124902206 Neighboring gene PEST containing nuclear protein pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91652935-91653434 Neighboring gene SHC adaptor protein 3 Neighboring gene negCOR silencer S5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91787594-91788094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91788095-91788595 Neighboring gene Sharpr-MPRA regulatory region 4063 Neighboring gene uncharacterized LOC105376136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:91896966-91897484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20005 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28527

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils. Van Koppen CJ, et al. Mol Pharmacol, 1996 Jun. PMID 8649355
  2. HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion. Sekine Y, et al. Prostate, 2011 May 15. PMID 20979115, Free PMC Article
  3. Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury. Sun X, et al. Am J Respir Cell Mol Biol, 2012 Nov. PMID 22771388, Free PMC Article
  4. Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). Jongsma M, et al. Br J Pharmacol, 2009 Apr. PMID 19309361, Free PMC Article
  5. Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation. Singleton PA, et al. Am J Respir Cell Mol Biol, 2007 Aug. PMID 17395891

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway.
    Title: SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway.
  2. Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of high-density lipoproteins and low-density lipoproteins in opposite ways.
    Title: Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of high-density lipoproteins and low-density lipoproteins in opposite ways.
  3. Extracellular alpha-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells.
    Title: Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells.
  4. Sphingosine 1-Phosphate Activates S1PR3 to Induce a Proinflammatory Phenotype in Human Myometrial Cells.
    Title: Sphingosine 1-Phosphate Activates S1PR3 to Induce a Proinflammatory Phenotype in Human Myometrial Cells.
  5. Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM).
    Title: Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM).
  6. The lncRNA H19/miR-766-3p/S1PR3 Axis Contributes to the Hyperproliferation of Keratinocytes and Skin Inflammation in Psoriasis via the AKT/mTOR Pathway.
    Title: The lncRNA H19/miR-766-3p/S1PR3 Axis Contributes to the Hyperproliferation of Keratinocytes and Skin Inflammation in Psoriasis via the AKT/mTOR Pathway.
  7. Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.
    Title: Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.
  8. Sphingosine-1-phosphate receptor 3 is implicated in BBB injury via the CCL2-CCR2 axis following acute intracerebral hemorrhage.
    Title: Sphingosine-1-phosphate receptor 3 is implicated in BBB injury via the CCL2-CCR2 axis following acute intracerebral hemorrhage.
  9. EGR2-mediated regulation of m(6)A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization.
    Title: EGR2-mediated regulation of m(6)A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization.
  10. Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation.
    Title: Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation.
Submit: New GeneRIF Correction See all GeneRIFs (67)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ27140, FLJ37523, FLJ45957, FLJ93220, MGC71696, MGC168509, MGC177970, DKFZp547B028

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipid binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sphingosine-1-phosphate receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in anatomical structure morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine-1-phosphate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sphingosine 1-phosphate receptor 3
Names
G protein-coupled receptor, endothelial differentiation gene-3
S1P receptor 3
S1P receptor EDG3
S1P receptor Edg-3
endothelial differentiation G-protein coupled receptor 3
endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
sphingosine 1-phosphate receptor Edg-3
uncharacterized protein C9orf47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395848.1 → NP_001382777.1  sphingosine 1-phosphate receptor 3

    Status: REVIEWED

    Source sequence(s)
    AL772202
    Consensus CDS
    CCDS6680.1
    UniProtKB/Swiss-Prot
    Q5SQD8, Q7Z5I2, Q99500
    Conserved Domains (1) summary
    cd15345
    Location:40 → 309
    7tmA_S1PR3_Edg3; sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_005226.4 → NP_005217.2  sphingosine 1-phosphate receptor 3

    See identical proteins and their annotated locations for NP_005217.2

    Status: REVIEWED

    Source sequence(s)
    BC060827, BM990167, DR763542
    Consensus CDS
    CCDS6680.1
    UniProtKB/Swiss-Prot
    Q5SQD8, Q7Z5I2, Q99500
    Related
    ENSP00000350878.2, ENST00000358157.3
    Conserved Domains (1) summary
    cd15345
    Location:40 → 309
    7tmA_S1PR3_Edg3; sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_172882.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL772202
    Related
    ENST00000648341.1

  2. NR_172883.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL772202
    Related
    ENST00000334490.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    88990863..89005155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    101153351..101167644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001938.4: Suppressed sequence

    Description
    NM_001001938.4: This RefSeq was removed because currently there is support for the transcript but not for the protein.

  2. NM_001142413.2: Suppressed sequence

    Description
    NM_001142413.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99500.2 GenPept UniProtKB/Swiss-Prot:Q99500

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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