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sinh-1 Stress-activated map kinase-interacting protein 1 homolog [ Caenorhabditis elegans ]

Gene ID: 190339, updated on 2-Nov-2024

Summary

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Official Symbol
sinh-1
Official Full Name
Stress-activated map kinase-interacting protein 1 homolog
Primary source
WormBase:WBGene00013261
Locus tag
CELE_Y57A10A.20
See related
AllianceGenome:WB:WBGene00013261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Involved in mesendoderm development. Predicted to be part of TORC2 complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human MAPKAP1 (MAPK associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sinh-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (12228305..12238242)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MATH domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene SRRM2 protein homolog rsr-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C. elegans. Longman D, et al. Curr Biol, 2001 Dec 11. PMID 11747818
  2. The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans. Sakai N, et al. PLoS One, 2017. PMID 28542414, Free PMC Article
  3. The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1. Yamashita M, et al. Biochem Biophys Res Commun, 2009 Jan 16. PMID 19028454, Free PMC Article
  4. GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate. Emans SW, et al. Development, 2023 Dec 15. PMID 37982457,
  5. TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Ruf V, et al. Dev Biol, 2013 Dec 15. PMID 23973804, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that a novel molecular interaction between the AEX-1 and syntaxin may regulate vesicle exocytosis for retrograde signal release.
    Title: The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mesendoderm development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Stress-activated map kinase-interacting protein 1 homolog
NP_496596.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    12228305..12238242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064195.5 → NP_496596.3  Stress-activated map kinase-interacting protein 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496596.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NA80
    Conserved Domains (2) summary
    pfam05422
    Location:18 → 117
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:129 → 263
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NA80.3

Gene LinkOut

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