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hhat-2 Homolog of Hedgehog AcylTransferase [ Caenorhabditis elegans ]

Gene ID: 190374, updated on 2-Nov-2024

Summary

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Official Symbol
hhat-2
Official Full Name
Homolog of Hedgehog AcylTransferase
Primary source
WormBase:WBGene00013312
Locus tag
CELE_Y57G11C.17
See related
AllianceGenome:WB:WBGene00013312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable palmitoyltransferase activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in chondrodysplasia-pseudohermaphroditism syndrome. Orthologous to human HHAT (hedgehog acyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hhat-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (14826428..14829126, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Translocon Sec61/SecY plug domain-containing protein Neighboring gene Small ribosomal subunit protein uS13 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Homologs of the Hh signalling network in C. elegans. Bürglin TR, et al. WormBook, 2006 Jan 28. PMID 18050469, Free PMC Article
  2. Meta-Analysis of Caenorhabditis elegans Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions. Zárate-Potes A, et al. Front Microbiol, 2022. PMID 35620104, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homolog of Hedgehog AcylTransferase
NP_001255840.1
  • Product from WormBase gene class hhat;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    14826428..14829126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268911.4 → NP_001255840.1  Homolog of Hedgehog AcylTransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255840.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18241
    Conserved Domains (1) summary
    cl00738
    Location:226 → 414
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RNA

  1. NR_060808.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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