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npr-5 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 190386, updated on 2-Nov-2024

Summary

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Official Symbol
npr-5
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein
Primary source
WormBase:WBGene00021983
Locus tag
CELE_Y58G8A.4
See related
AllianceGenome:WB:WBGene00021983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable neuropeptide binding activity and neuropeptide receptor activity. Involved in regulation of muscle contraction. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in body wall musculature; chemosensory neurons; head neurons; and muscle cell. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See npr-5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (276985..281716, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene Secreted protein Neighboring gene 'chromo' domain containing protein;Mediator complex subunit 6 Neighboring gene Protein phosphatase 1 regulatory subunit 21 N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells. Kubiak TM, et al. Biopolymers, 2008. PMID 17879267
  2. Control of Locomotory Behavior of Caenorhabditis elegans by the Immunoglobulin Superfamily Protein RIG-3. Bhardwaj A, et al. Genetics, 2020 Jan. PMID 31740450, Free PMC Article
  3. Coordinated regulation of foraging and metabolism in C. elegans by RFamide neuropeptide signaling. Cohen M, et al. Cell Metab, 2009 Apr. PMID 19356718
  4. Co-transmission of neuropeptides and monoamines choreograph the C. elegans escape response. Florman JT, et al. PLoS Genet, 2022 Mar. PMID 35239681, Free PMC Article
  5. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Lemieux GA, et al. Cell, 2015 Jan 15. PMID 25594177, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of muscle contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein
NP_001024264.1
  • Confirmed by transcript evidence
NP_001024265.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    276985..281716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029093.5 → NP_001024264.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024264.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZY4
    Conserved Domains (1) summary
    cd15203
    Location:56 → 347
    7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001029094.5 → NP_001024265.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024265.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6F3C9
    Conserved Domains (1) summary
    cd15203
    Location:56 → 347
    7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
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