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trp-4 Ion transport domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 190574, updated on 2-Nov-2024

Summary

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Official Symbol
trp-4
Official Full Name
Ion transport domain-containing protein
Primary source
WormBase:WBGene00006616
Locus tag
CELE_Y71A12B.4
See related
AllianceGenome:WB:WBGene00006616
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be active in membrane. Is expressed in ciliated neurons; dopaminergic neurons; dorsal-rectal ganglion neurons; head mesodermal cell; and rectum. Orthologous to human ANKRD28 (ankyrin repeat domain 28) and ANKRD44 (ankyrin repeat domain 44). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See trp-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
24
Sequence:
Chromosome: I; NC_003279.8 (13899085..13914008)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene PAN-3 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans. Ibsen S, et al. Nat Commun, 2015 Sep 15. PMID 26372413, Free PMC Article
  2. In touch - the molecular basis of mechanosensory transduction. Kang L, et al. Biochem (Lond), 2011 Dec. PMID 25598582, Free PMC Article
  3. Evolutionarily conserved mechanisms in calcium handling may underlie intrinsic sensitivity to dopaminergic neuron death. Taub DG. J Neurosci, 2014 Aug 13. PMID 25122882, Free PMC Article
  4. C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. Kang L, et al. Neuron, 2010 Aug 12. PMID 20696377, Free PMC Article
  5. Mechano-gated channels in C. elegans. Al-Sheikh U, et al. J Neurogenet, 2020 Sep-Dec. PMID 33325279

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuron-specific misexpression of TRP-4, the pore-forming subunit of a mechanotransduction channel, sensitizes neurons to ultrasound stimulus, resulting in behavioural outputs.
    Title: Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans.
  2. TRP-4 functions as an essential pore-forming subunit of a native mechanotransduction channel.
    Title: C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel.
  3. TRP-4 acts in a single neuron, DVA, to mediate its function in proprioception, and that the activity of DVA can be stimulated by body stretch
    Title: A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ion transport domain-containing protein
NP_493429.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13899085..13914008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061028.3 → NP_493429.2  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493429.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GRV5
    Conserved Domains (5) summary
    PHA02876
    Location:712 → 1040
    PHA02876; ankyrin repeat protein; Provisional
    PHA03095
    Location:430 → 756
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:280 → 515
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    TIGR00870
    Location:1209 → 1879
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:886 → 917
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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