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slc-30A9 Proton-coupled zinc antiporter SLC30A9, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 190608, updated on 2-Nov-2024

Summary

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Official Symbol
slc-30A9
Official Full Name
Proton-coupled zinc antiporter SLC30A9, mitochondrial
Primary source
WormBase:WBGene00022174
Locus tag
CELE_Y71H2AM.9
See related
AllianceGenome:WB:WBGene00022174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable monoatomic cation transmembrane transporter activity. Predicted to be involved in intracellular zinc ion homeostasis and zinc ion transport. Predicted to be located in mitochondrial membrane and nucleus. Predicted to be active in endoplasmic reticulum. Orthologous to human SLC30A9 (solute carrier family 30 member 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See slc-30A9 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (2690160..2698817, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene CX domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene protein-histidine N-methyltransferase Neighboring gene Transmembrane protein 132 homolog Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mutation in SLC30A9, a zinc transporter, causes an increased sensitivity to oxidative stress in the nematode Caenorhabditis elegans. En A, et al. Biochem Biophys Res Commun, 2022 Dec 17. PMID 36244116
  2. A pair of transporters controls mitochondrial Zn(2+) levels to maintain mitochondrial homeostasis. Ma T, et al. Protein Cell, 2022 Mar. PMID 34687432, Free PMC Article
  3. SLC-30A9 is required for Zn(2+) homeostasis, Zn(2+) mobilization, and mitochondrial health. Deng H, et al. Proc Natl Acad Sci U S A, 2021 Aug 31. PMID 34433664, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mutation in SLC30A9, a zinc transporter, causes an increased sensitivity to oxidative stress in the nematode Caenorhabditis elegans.
    Title: A mutation in SLC30A9, a zinc transporter, causes an increased sensitivity to oxidative stress in the nematode Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Proton-coupled zinc antiporter SLC30A9, mitochondrial
NP_497603.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2690160..2698817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065202.7 → NP_497603.3  Proton-coupled zinc antiporter SLC30A9, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497603.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SSS9, Q3V5J4
    Conserved Domains (2) summary
    cl30791
    Location:159 → 406
    FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]
    cl27062
    Location:68 → 157
    XPA_C; XPA protein C-terminus
Nucleotide Protein
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