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Y71H2AR.2 Peptidase C1A papain C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 190615, updated on 2-Nov-2024

Summary

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Official Symbol
Y71H2AR.2
Official Full Name
Peptidase C1A papain C-terminal domain-containing protein
Primary source
WormBase:WBGene00022189
Locus tag
CELE_Y71H2AR.2
See related
AllianceGenome:WB:WBGene00022189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in membrane. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in neuropathy and pycnodysostosis. Orthologous to human CTSK (cathepsin K) and CTSS (cathepsin S). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y71H2AR.2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (2839120..2840927, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Thioredoxin domain-containing protein 17 Neighboring gene ubiquitinyl hydrolase 1 Neighboring gene CUB domain-containing protein Neighboring gene Conserved secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Peptidase C1A papain C-terminal domain-containing protein
NP_001367938.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2839120..2840927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381789.1 → NP_001367938.1  Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL26
    Conserved Domains (1) summary
    cd02248
    Location:84 → 290
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
Nucleotide Protein
Heading Accession and Version

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