U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cng-2 Cyclic nucleotide-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 190732, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
cng-2
Official Full Name
Cyclic nucleotide-binding domain-containing protein
Primary source
WormBase:WBGene00022295
Locus tag
CELE_Y76B12C.1
See related
AllianceGenome:WB:WBGene00022295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cGMP binding activity; intracellularly cAMP-activated cation channel activity; and intracellularly cGMP-activated cation channel activity. Predicted to be involved in monoatomic cation transmembrane transport. Located in neuronal cell body. Is expressed in amphid neurons. Human ortholog(s) of this gene implicated in achromatopsia 2; color blindness; retinitis pigmentosa; and retinitis pigmentosa 49. Orthologous to several human genes including CNGA1 (cyclic nucleotide gated channel subunit alpha 1); CNGA2 (cyclic nucleotide gated channel subunit alpha 2); and CNGA3 (cyclic nucleotide gated channel subunit alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cng-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
14
Sequence:
Chromosome: IV; NC_003282.8 (2037191..2043549)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein;MMS1_N domain-containing protein;putative cleavage and polyadenylation specificity factor subunit 1 Neighboring gene NUP50 domain-containing protein Neighboring gene ncRNA Neighboring gene Ovule protein;Protein shisa-9

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans. Park J, et al. PLoS Genet, 2020 Aug. PMID 32776934, Free PMC Article
  2. A new putative cyclic nucleotide-gated channel gene, cng-3, is critical for thermotolerance in Caenorhabditis elegans. Cho SW, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530424
  3. Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans. Wojtyniak M, et al. J Cell Sci, 2013 Oct 1. PMID 23886944, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly cAMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly cGMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of intracellular cyclic nucleotide activated cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Cyclic nucleotide-binding domain-containing protein
NP_001294580.1
  • Confirmed by transcript evidence
NP_001343690.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2037191..2043549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356909.3 → NP_001343690.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4C1
    Conserved Domains (3) summary
    PLN03192
    Location:457 → 713
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00038
    Location:594 → 711
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:232 → 407
    Ion_trans; Ion transport protein

  2. NM_001307651.3 → NP_001294580.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294580.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PCB8
    Conserved Domains (1) summary
    cd00038
    Location:3 → 104
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools