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gpx-4 Glutathione peroxidase [ Caenorhabditis elegans ]

Gene ID: 190801, updated on 2-Nov-2024

Summary

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Official Symbol
gpx-4
Official Full Name
Glutathione peroxidase
Primary source
WormBase:WBGene00022377
Locus tag
CELE_Y94H6A.4
See related
AllianceGenome:WB:WBGene00022377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; cerebral infarction; gastrointestinal system cancer (multiple); multiple myeloma; and type 2 diabetes mellitus. Orthologous to human GPX3 (glutathione peroxidase 3) and GPX5 (glutathione peroxidase 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gpx-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (2672962..2675015, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Brix domain-containing protein;DUF1902 domain-containing protein;Uncharacterized protein Neighboring gene PRP16 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toxicity of Three Optical Brighteners: Potential Pharmacological Targets and Effects on Caenorhabditis elegans. Castro-Sierra I, et al. Toxics, 2024 Jan 9. PMID 38251007, Free PMC Article
  2. Toxicity of atrazine- and glyphosate-based formulations on Caenorhabditis elegans. García-Espiñeira M, et al. Ecotoxicol Environ Saf, 2018 Jul 30. PMID 29550685
  3. Toxicity of nonylphenol and nonylphenol ethoxylate on Caenorhabditis elegans. De la Parra-Guerra A, et al. Ecotoxicol Environ Saf, 2020 Jan 15. PMID 31654870
  4. Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans. Sakamoto T, et al. Genes Cells, 2014 Oct. PMID 25200408
  5. Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans. Song S, et al. PLoS One, 2014. PMID 25243607, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Glutathione peroxidase
NP_500242.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2672962..2675015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067841.5 → NP_500242.2  Glutathione peroxidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500242.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N2X2
    Conserved Domains (1) summary
    cl00388
    Location:39 → 116
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
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