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spl-3 Sphingosine Phosphate Lyase [ Caenorhabditis elegans ]

Gene ID: 190868, updated on 2-Nov-2024

Summary

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Official Symbol
spl-3
Official Full Name
Sphingosine Phosphate Lyase
Primary source
WormBase:WBGene00022427
Locus tag
CELE_Y104H12D.3
See related
AllianceGenome:WB:WBGene00022427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sphinganine-1-phosphate aldolase activity. Predicted to be involved in sphingolipid catabolic process. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spl-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (1193065..1201901)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RecQ-mediated genome instability protein 2 homolog Neighboring gene Mediator of RNA polymerase II transcription subunit 20 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Delta-like protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables sphinganine-1-phosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sphingosine Phosphate Lyase
NP_001350992.1
  • Product from WormBase gene class spl;
    Confirmed by transcript evidence
NP_001368265.1
  • Product from WormBase gene class spl;
    Confirmed by transcript evidence
NP_500051.2
  • Product from WormBase gene class spl;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1193065..1201901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067650.5 → NP_500051.2  Sphingosine Phosphate Lyase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500051.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q966E7
    Conserved Domains (1) summary
    cd06450
    Location:147 → 502
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

  2. NM_001364040.1 → NP_001350992.1  Sphingosine Phosphate Lyase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X0T211
    Conserved Domains (1) summary
    cl18945
    Location:147 → 362
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  3. NM_001380038.1 → NP_001368265.1  Sphingosine Phosphate Lyase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBG7
    Conserved Domains (1) summary
    cl18945
    Location:1 → 235
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein
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