Y106G6E.4 putative 5-formyltetrahydrofolate cyclo-ligase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y106G6E.4
Official Full Name: putative 5-formyltetrahydrofolate cyclo-ligase
Primary source: WormBase:WBGene00013708
Locus tag: CELE_Y106G6E.4
See related: AllianceGenome:WB:WBGene00013708
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity. Predicted to be involved in folic acid-containing compound biosynthetic process and tetrahydrofolate interconversion. Predicted to be active in mitochondrion. Orthologous to human MTHFS (methenyltetrahydrofolate synthetase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y106G6E.4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (10221642..10222778, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y106G6E.5 (e-PCR)
- UniSTS:312974

Y106G6E.4 (e-PCR)
- UniSTS:316151

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 5-formyltetrahydrofolate cyclo-ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5-formyltetrahydrofolate cyclo-ligase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in folic acid-containing compound biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrofolate interconversion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative 5-formyltetrahydrofolate cyclo-ligase

NP_492692.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10221642..10222778 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060291.7 → NP_492692.1 putative 5-formyltetrahydrofolate cyclo-ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492692.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XWE6

Conserved Domains (1) summary

pfam01812
Location:8 → 197

5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family