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pinn-1 Peptidyl-prolyl cis-trans isomerase [ Caenorhabditis elegans ]

Gene ID: 190941, updated on 2-Nov-2024

Summary

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Official Symbol
pinn-1
Official Full Name
Peptidyl-prolyl cis-trans isomerase
Primary source
WormBase:WBGene00022448
Locus tag
CELE_Y110A2AL.13
See related
AllianceGenome:WB:WBGene00022448
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in regulation of macromolecule metabolic process and regulation of primary metabolic process. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including excretory cell; hypodermis; intestine; nervous system; and rectal gland cell. Orthologous to human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pinn-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (2885514..2889007, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Smr domain-containing protein Neighboring gene ncRNA Neighboring gene Phosphatidylinositol-glycan biosynthesis class W protein Neighboring gene Beta-1,3-galactosyltransferase sqv-2 Neighboring gene ncRNA Neighboring gene E2 ubiquitin-conjugating enzyme

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans parvulin gene subfamily and their expression under cold or heat stress along with the fkb subfamily. Fasseas MK, et al. Biochem Biophys Res Commun, 2012 Jul 6. PMID 22683625
  2. Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform in C. elegans epidermal development. Chen F, et al. Development, 2017 Feb 15. PMID 28087624, Free PMC Article
  3. Synaptic Protein Degradation Controls Sexually Dimorphic Circuits through Regulation of DCC/UNC-40. Salzberg Y, et al. Curr Biol, 2020 Nov 2. PMID 32857970, Free PMC Article
  4. Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin. LaBella ML, et al. Dev Cell, 2020 Jan 6. PMID 31910362, Free PMC Article
  5. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A peptidyl-prolyl isomerase PINN-1 antagonizes SYDN-1 in the spatiotemporal control of neuronal ankyrin isoform. Moreover, the nuclear localization of PINN-1 is altered in dapk-1 mutants.
    Title: Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform in C. elegans epidermal development.
  2. this work presents a first attempt to characterize the Caenorhabditis elegans parvulins.
    Title: The Caenorhabditis elegans parvulin gene subfamily and their expression under cold or heat stress along with the fkb subfamily.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of macromolecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of primary metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptidyl-prolyl cis-trans isomerase
NP_494393.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2885514..2889007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061992.6 → NP_494393.2  Peptidyl-prolyl cis-trans isomerase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494393.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N492
    Conserved Domains (3) summary
    PTZ00356
    Location:46 → 161
    PTZ00356; peptidyl-prolyl cis-trans isomerase (PPIase); Provisional
    COG0760
    Location:43 → 161
    SurA; Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:6 → 36
    WW; WW domain
Nucleotide Protein
Heading Accession and Version

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