rad-54.B DNA repair and recombination protein RAD54-like [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rad-54.B
Official Full Name: DNA repair and recombination protein RAD54-like
Primary source: WormBase:WBGene00013792
Locus tag: CELE_Y116A8C.13
See related: AllianceGenome:WB:WBGene00013792
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA translocase activity. Predicted to be involved in double-strand break repair via homologous recombination and reciprocal meiotic recombination. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Orthologous to human RAD54B (RAD54 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rad-54.B in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (16950067..16962868)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells.
Title: Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y116A8C.13 (e-PCR)
- UniSTS:321831

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA translocase activity	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA repair and recombination protein RAD54-like

NP_001255913.1

Confirmed by transcript evidence

NP_001255914.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

16950067..16962868

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268984.2 → NP_001255913.1 DNA repair and recombination protein RAD54-like [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255913.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U2S8

Conserved Domains (3) summary

cd00046
Location:235 → 374

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:209 → 480

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:516 → 631

Helicase_C; Helicase conserved C-terminal domain
NM_001268985.3 → NP_001255914.1 DNA repair and recombination protein RAD54-like [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255914.1

Status: REVIEWED

UniProtKB/TrEMBL

D3NQA7

Conserved Domains (3) summary

cd00046
Location:122 → 261

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:96 → 367

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:403 → 518

Helicase_C; Helicase conserved C-terminal domain