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best-22 Bestrophin homolog;Bestrophin homolog 22 [ Caenorhabditis elegans ]

Gene ID: 191197, updated on 2-Nov-2024

Summary

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Official Symbol
best-22
Official Full Name
Bestrophin homolog;Bestrophin homolog 22
Primary source
WormBase:WBGene00013921
Locus tag
CELE_ZC518.1
See related
AllianceGenome:WB:WBGene00013921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human BEST2 (bestrophin 2) and BEST4 (bestrophin 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See best-22 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
14
Sequence:
Chromosome: IV; NC_003282.8 (12349939..12355724)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Glutathione S-transferase Neighboring gene poly(A)-specific ribonuclease Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bestrophin homolog;Bestrophin homolog 22
NP_001122833.1
  • Confirmed by transcript evidence
NP_001263798.1
  • Confirmed by transcript evidence
NP_001293988.1
  • Confirmed by transcript evidence
NP_001293989.1
  • Confirmed by transcript evidence
NP_001359653.1
  • Confirmed by transcript evidence
NP_502353.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12349939..12355724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307059.3 → NP_001293988.1  Bestrophin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293988.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AJF0
    Conserved Domains (1) summary
    pfam01062
    Location:8 → 314
    Bestrophin; Bestrophin, RFP-TM, chloride channel

  2. NM_001307060.3 → NP_001293989.1  Bestrophin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293989.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AL29
    Conserved Domains (1) summary
    pfam01062
    Location:8 → 314
    Bestrophin; Bestrophin, RFP-TM, chloride channel

  3. NM_001372938.2 → NP_001359653.1  Bestrophin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4B3
    Conserved Domains (1) summary
    pfam01062
    Location:8 → 314
    Bestrophin; RFP-TM, chloride channel

  4. NM_001276869.3 → NP_001263798.1  Bestrophin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    J7SEZ5
    Conserved Domains (1) summary
    pfam01062
    Location:8 → 314
    Bestrophin; RFP-TM, chloride channel

  5. NM_069952.9 → NP_502353.1  Bestrophin homolog 22 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502353.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23369
    Conserved Domains (1) summary
    pfam01062
    Location:8 → 314
    Bestrophin; Bestrophin, RFP-TM, chloride channel

  6. NM_001129361.5 → NP_001122833.1  Bestrophin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122833.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7UQ07
    Conserved Domains (1) summary
    pfam01062
    Location:8 → 314
    Bestrophin; Bestrophin, RFP-TM, chloride channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23369.1

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