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irg-8 CUB_2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 191209, updated on 2-Nov-2024

Summary

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Official Symbol
irg-8
Official Full Name
CUB_2 domain-containing protein
Primary source
WormBase:WBGene00022645
Locus tag
CELE_ZK6.11
See related
AllianceGenome:WB:WBGene00022645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in innate immune response. Located in membrane raft. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See irg-8 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (415870..417706, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Downstream Of DAF-16 (regulated by DAF-16);GH131_N domain-containing protein;IgGFc_binding domain-containing protein Neighboring gene UNC93-like protein MFSD11 Neighboring gene Downstream Of DAF-16 (regulated by DAF-16)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of differentially expressed genes in Caenorhabditis elegans in response to pathogenic and nonpathogenic Stenotrophomonas maltophilia. Radeke LJ, et al. BMC Microbiol, 2020 Jun 19. PMID 32560629, Free PMC Article
  2. The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans. Takagaki N, et al. EMBO Rep, 2020 Mar 4. PMID 32009302, Free PMC Article
  3. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894
  4. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  5. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in innate immune response HEP PubMed 
Component Evidence Code Pubs
located_in membrane raft HDA PubMed 

General protein information

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Preferred Names
CUB_2 domain-containing protein
NP_001024314.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    415870..417706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029143.4 → NP_001024314.1  CUB_2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024314.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0Q1, Q6EZG8
    Conserved Domains (1) summary
    pfam03409
    Location:44 → 373
    Glycoprotein; Transmembrane glycoprotein
Nucleotide Protein
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