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dhrr-1 G_PROTEIN_RECEP_F2_4 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 191374, updated on 2-Nov-2024

Summary

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Official Symbol
dhrr-1
Official Full Name
G_PROTEIN_RECEP_F2_4 domain-containing protein
Primary source
WormBase:WBGene00014035
Locus tag
CELE_ZK643.3
See related
AllianceGenome:WB:WBGene00014035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in M.vlpaaapp; M.vlpaapaa; M.vrpaaapp; M.vrpaapaa; and head muscle. Human ortholog(s) of this gene implicated in achalasia; isolated growth hormone deficiency; isolated growth hormone deficiency type IB; and obesity. Orthologous to several human genes including ADCYAP1R1 (ADCYAP receptor type I); GLP1R (glucagon like peptide 1 receptor); and GHRHR (growth hormone releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dhrr-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (8944686..8952953)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Arrestin C-terminal-like domain-containing protein;Arrestin domain-containing protein 15 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene putative deoxycytidylate deaminase Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene GRound-Like (grd related)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Family-B G-protein-coupled receptors. Harmar AJ. Genome Biol, 2001. PMID 11790261, Free PMC Article
  2. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
  3. System-wide mapping of peptide-GPCR interactions in C. elegans. Beets I, et al. Cell Rep, 2023 Sep 26. PMID 37656621, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G_PROTEIN_RECEP_F2_4 domain-containing protein
NP_001122749.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8944686..8952953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129277.5 → NP_001122749.1  G_PROTEIN_RECEP_F2_4 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122749.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30649, P30650
    UniProtKB/TrEMBL
    A7LPE2
    Conserved Domains (2) summary
    smart00008
    Location:142 → 222
    HormR; Domain present in hormone receptors
    cl21561
    Location:230 → 466
    7tm_4; Olfactory receptor
Nucleotide Protein
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