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ZK697.8 putative 5-hydroxyisourate hydrolase ZK697.8 [ Caenorhabditis elegans ]

Gene ID: 191414, updated on 2-Nov-2024

Summary

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Official Symbol
ZK697.8
Official Full Name
putative 5-hydroxyisourate hydrolase ZK697.8
Primary source
WormBase:WBGene00022808
Locus tag
CELE_ZK697.8
See related
AllianceGenome:WB:WBGene00022808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydroxyisourate hydrolase activity. Predicted to be involved in purine nucleobase metabolic process. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome 1; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ZK697.8 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (1748432..1749153, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene NR LBD domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class Z

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyisourate hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in purine nucleobase metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative 5-hydroxyisourate hydrolase ZK697.8
NP_503496.2
  • Predicted

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1748432..1749153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071095.2 → NP_503496.2  putative 5-hydroxyisourate hydrolase ZK697.8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503496.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44578
    Conserved Domains (1) summary
    cd05822
    Location:28 → 136
    TLP_HIUase; HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44578.2

Gene LinkOut

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