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acr-11 AcetylCholine Receptor [ Caenorhabditis elegans ]

Gene ID: 191599, updated on 2-Nov-2024

Summary

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Official Symbol
acr-11
Official Full Name
AcetylCholine Receptor
Primary source
WormBase:WBGene00000050
Locus tag
CELE_D2092.3
See related
AllianceGenome:WB:WBGene00000050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acetylcholine receptor activity; excitatory extracellular ligand-gated monoatomic ion channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in chemical synaptic transmission. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acr-11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (6621624..6624918, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene TetraSPanin family Neighboring gene Translation initiation factor IF-2 Neighboring gene Protein Phosphatase Four Regulatory subunit Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drug-dependent behaviors and nicotinic acetylcholine receptor expressions in Caenorhabditis elegans following chronic nicotine exposure. Polli JR, et al. Neurotoxicology, 2015 Mar. PMID 25530353, Free PMC Article
  2. An extensive and diverse gene family of nicotinic acetylcholine receptor alpha subunits in Caenorhabditis elegans. Mongan NP, et al. Recept Channels, 1998. PMID 10100329
  3. A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels. Feng Z, et al. Cell, 2006 Nov 3. PMID 17081982, Free PMC Article
  4. The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction. Francis MM, et al. Neuron, 2005 May 19. PMID 15944127
  5. Nicotine Motivated Behavior in C. elegans. Salim C, et al. Int J Mol Sci, 2024 Jan 29. PMID 38338915, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acetylcholine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IC
Inferred by Curator
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AcetylCholine Receptor
NP_491906.1
  • Product from WormBase gene class acr;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6621624..6624918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059505.2 → NP_491906.1  AcetylCholine Receptor [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491906.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91197
    Conserved Domains (3) summary
    TIGR00860
    Location:25 → 456
    LIC; Cation transporter family protein
    pfam02931
    Location:26 → 239
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:246 → 447
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein
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