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acr-17 AcetylCholine Receptor;Neur_chan_memb domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 191603, updated on 2-Nov-2024

Summary

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Official Symbol
acr-17
Official Full Name
AcetylCholine Receptor;Neur_chan_memb domain-containing protein
Primary source
WormBase:WBGene00000056
Locus tag
CELE_F53E10.2
See related
AllianceGenome:WB:WBGene00000056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acr-17 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (2608652..2615262)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene RRP15-like protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene MOSC domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction. Francis MM, et al. Neuron, 2005 May 19. PMID 15944127
  2. Novel alpha7-like nicotinic acetylcholine receptor subunits in the nematode Caenorhabditis elegans. Mongan NP, et al. Protein Sci, 2002 May. PMID 11967372, Free PMC Article
  3. The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit. Culetto E, et al. J Biol Chem, 2004 Oct 8. PMID 15280391
  4. Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans. Jones AK, et al. Bioessays, 2004 Jan. PMID 14696039
  5. An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction. Sando SR, et al. Elife, 2021 Jul 2. PMID 34212858, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AcetylCholine Receptor;Neur_chan_memb domain-containing protein
NP_001023961.1
  • Product from WormBase gene class acr;
    Confirmed by transcript evidence
NP_001303731.1
  • Confirmed by transcript evidence
NP_001303732.1
  • Confirmed by transcript evidence
NP_001303733.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    2608652..2615262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316802.4 → NP_001303731.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0M7RFG1, Q6QWI8
    Conserved Domains (3) summary
    TIGR00860
    Location:23 → 463
    LIC; Cation transporter family protein
    pfam02931
    Location:24 → 245
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:252 → 463
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_001028790.7 → NP_001023961.1  AcetylCholine Receptor [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023961.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6F6K3, Q6QWI8
    Conserved Domains (3) summary
    TIGR00860
    Location:23 → 491
    LIC; Cation transporter family protein
    pfam02931
    Location:24 → 245
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:252 → 491
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  3. NM_001316803.3 → NP_001303732.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0M7RDU0
    Conserved Domains (1) summary
    pfam02932
    Location:9 → 54
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  4. NM_001316804.3 → NP_001303733.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0M7REC3

RNA

  1. NR_133607.1 RNA Sequence

    Status: REVIEWED

  2. NR_133608.1 RNA Sequence

    Status: REVIEWED

  3. NR_133609.1 RNA Sequence

    Status: REVIEWED

  4. NR_133611.1 RNA Sequence

    Status: REVIEWED

  5. NR_133610.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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