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cdc-25.4 M-phase inducer phosphatase [ Caenorhabditis elegans ]

Gene ID: 191612, updated on 2-Nov-2024

Summary

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Official Symbol
cdc-25.4
Official Full Name
M-phase inducer phosphatase
Primary source
WormBase:WBGene00000389
Locus tag
CELE_R05H5.2
See related
AllianceGenome:WB:WBGene00000389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of G2/MI transition of meiotic cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including ganglia; germ line; pharyngeal cell; ventral nerve cord; and in male. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cdc-25.4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (10188258..10189469, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class delta-1 Neighboring gene ncRNA Neighboring gene Serpentine receptor class delta-2 Neighboring gene WAP domain-containing protein Neighboring gene Serpentine receptor class beta-6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cdc-25.4, a Caenorhabditis elegans Ortholog of cdc25, Is Required for Male Mating Behavior. Oh S, et al. G3 (Bethesda), 2016 Dec 7. PMID 27770028, Free PMC Article
  2. Identification of cdc25 gene in pinewood nematode, Bursaphelenchus xylophilus, and its function in reproduction. Choi YN, et al. Mol Cells, 2010 Feb 28. PMID 20069382
  3. CDC-25.1 regulates germline proliferation in Caenorhabditis elegans. Ashcroft N, et al. Genesis, 2002 May. PMID 12001064
  4. The four cdc25 genes from the nematode Caenorhabditis elegans. Ashcroft NR, et al. Gene, 1998 Jul 3. PMID 9651482
  5. Cell-cycle regulation. van den Heuvel S. WormBook, 2005 Sep 21. PMID 18050422, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell cycle G2/M phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
M-phase inducer phosphatase
NP_496197.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10188258..10189469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063796.5 → NP_496197.2  M-phase inducer phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496197.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21762
    Conserved Domains (1) summary
    cd01530
    Location:58 → 176
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
Nucleotide Protein
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