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ceh-40 Homeobox protein ceh-40 [ Caenorhabditis elegans ]

Gene ID: 191624, updated on 2-Nov-2024

Summary

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Official Symbol
ceh-40
Official Full Name
Homeobox protein ceh-40
Primary source
WormBase:WBGene00000461
Locus tag
CELE_F17A2.5
See related
AllianceGenome:WB:WBGene00000461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dopaminergic neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ceh-40 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (12318126..12320777, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Histone deacetylase 14 Neighboring gene pseudo Neighboring gene MX region of TRA-2 Related Neighboring gene Uncharacterized protein Neighboring gene Serpentine receptor class delta-40 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Aspöck G, et al. Development, 2003 Aug. PMID 12810585
  2. Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1. Liu H, et al. Development, 2006 Feb. PMID 16421192
  3. A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans. Doitsidou M, et al. Genes Dev, 2013 Jun 15. PMID 23788625, Free PMC Article
  4. Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis. Van Auken K, et al. Development, 2002 Nov. PMID 12399316
  5. Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20. Jiang Y, et al. Mech Dev, 2008 May-Jun. PMID 18316179, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homeobox protein ceh-40
NP_510060.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    12318126..12320777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077659.4 → NP_510060.1  Homeobox protein ceh-40 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510060.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19503
    Conserved Domains (2) summary
    cd00086
    Location:188 → 249
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:5 → 186
    PBC; PBC domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19503.1

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