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ced-13 Secreted protein [ Caenorhabditis elegans ]

Gene ID: 191625, updated on 18-Sep-2024

Summary

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Official Symbol
ced-13
Official Full Name
Secreted protein
Primary source
WormBase:WBGene00000427
Locus tag
CELE_R09F10.9
See related
AllianceGenome:WB:WBGene00000427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables BH domain binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and positive regulation of apoptotic process. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ced-13 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (8299119..8299654, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Mediator of RNA polymerase II transcription subunit 27 Neighboring gene ncRNA Neighboring gene Innexin-5 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential regulation of germline apoptosis in response to meiotic checkpoint activation. Ye AL, et al. Genetics, 2014 Nov. PMID 25217053, Free PMC Article
  2. The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Yee C, et al. Cell, 2014 May 8. PMID 24813612, Free PMC Article
  3. CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13. Fairlie WD, et al. Cell Death Differ, 2006 Mar. PMID 16167070
  4. Internal concentrations of perfluorobutane sulfonate (PFBS) comparable to those of perfluorooctane sulfonate (PFOS) induce reproductive toxicity in Caenorhabditis elegans. Chen F, et al. Ecotoxicol Environ Saf, 2018 Aug 30. PMID 29705512
  5. Dopamine neuron degeneration induced by MPP+ is independent of CED-4 pathway in Caenorhabditis elegans. Pu P, et al. Cell Res, 2008 Sep. PMID 19160545

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables BH domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
Secreted protein
NP_509402.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8299119..8299654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077001.2 → NP_509402.1  Secreted protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509402.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TY06
    Conserved Domains (1) summary
    pfam11430
    Location:53 → 72
    EGL-1; Programmed cell death activator EGL-1
Nucleotide Protein
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