lgc-58 Ligand-Gated ion Channel [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lgc-58
Official Full Name: Ligand-Gated ion Channel
Primary source: WormBase:WBGene00001587
Locus tag: CELE_C45B2.4
See related: AllianceGenome:WB:WBGene00001587
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in nerve ring and neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lgc-58 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 15

Sequence:: Chromosome: X; NC_003284.9 (6075509..6081881)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

STS6-145 (e-PCR)
- UniSTS:242525

C45B2.4 (e-PCR)
- UniSTS:313054

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ligand-Gated ion Channel

NP_001024472.2

Confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001367470.1

Confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368736.1

Partially confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368737.1

Confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368738.1

Partially confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368739.1

Partially confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368740.1

Confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368741.1

Partially confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368742.1

Confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368743.1

Partially confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368744.1

Confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368745.1

Partially confirmed by transcript evidence;
Product from WormBase gene class lgc

NP_001368746.1

Confirmed by transcript evidence;
Product from WormBase gene class lgc

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

6075509..6081881

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029301.7 → NP_001024472.2 Ligand-Gated ion Channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024472.2

Status: REVIEWED

UniProtKB/TrEMBL

Q2WF65

Conserved Domains (3) summary

TIGR00860
Location:30 → 541

LIC; Cation transporter family protein

pfam02931
Location:41 → 237

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:245 → 538

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001380998.2 → NP_001368746.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0IKP2

Conserved Domains (1) summary

TIGR00860
Location:30 → 502

LIC; Cation transporter family protein
NM_001380992.2 → NP_001368740.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0IKB1

Conserved Domains (1) summary

TIGR00860
Location:30 → 513

LIC; Cation transporter family protein
NM_001380988.1 → NP_001368738.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0IN81

Conserved Domains (1) summary

TIGR00860
Location:30 → 548

LIC; Cation transporter family protein
NM_001380989.1 → NP_001368736.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0IKM8

Conserved Domains (1) summary

TIGR00860
Location:30 → 535

LIC; Cation transporter family protein
NM_001380990.1 → NP_001368737.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0INF0

Conserved Domains (1) summary

TIGR00860
Location:30 → 528

LIC; Cation transporter family protein
NM_001380991.1 → NP_001368739.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V6M3Y9

Conserved Domains (1) summary

TIGR00860
Location:30 → 520

LIC; Cation transporter family protein
NM_001380993.1 → NP_001368743.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0ILX4

Conserved Domains (1) summary

TIGR00860
Location:30 → 537

LIC; Cation transporter family protein
NM_001380994.1 → NP_001368744.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0IK93

Conserved Domains (1) summary

TIGR00860
Location:30 → 530

LIC; Cation transporter family protein
NM_001380995.1 → NP_001368741.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0IJ32

Conserved Domains (1) summary

TIGR00860
Location:30 → 524

LIC; Cation transporter family protein
NM_001380996.1 → NP_001368742.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0ILI0

Conserved Domains (1) summary

TIGR00860
Location:30 → 517

LIC; Cation transporter family protein
NM_001380997.1 → NP_001368745.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0IK64

Conserved Domains (1) summary

TIGR00860
Location:30 → 509

LIC; Cation transporter family protein
NM_001380999.1 → NP_001367470.1 Ligand-Gated ion Channel [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KYL4

Conserved Domains (1) summary

TIGR00860
Location:30 → 423

LIC; Cation transporter family protein