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gcy-19 Guanylate cyclase [ Caenorhabditis elegans ]

Gene ID: 191650, updated on 2-Nov-2024

Summary

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Official Symbol
gcy-19
Official Full Name
Guanylate cyclase
Primary source
WormBase:WBGene00001544
Locus tag
CELE_C17F4.6
See related
AllianceGenome:WB:WBGene00001544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gcy-19 in Genome Data Viewer
Location:
chromosome: II
Exon count:
23
Sequence:
Chromosome: II; NC_003280.10 (3250975..3259354, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene Secreted protein Neighboring gene Citrate-sodium symporter;MFS transporter;SLC36A1 Neighboring gene tRNA-Ser

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases. Ortiz CO, et al. Curr Biol, 2009 Jun 23. PMID 19523832, Free PMC Article
  2. Cis-regulatory mechanisms of left/right asymmetric neuron-subtype specification in C. elegans. Etchberger JF, et al. Development, 2009 Jan. PMID 19060335, Free PMC Article
  3. Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Ortiz CO, et al. Genetics, 2006 May. PMID 16547101, Free PMC Article
  4. The neural basis of heat seeking in a human-infective parasitic worm. Bryant AS, et al. Curr Biol, 2022 May 23. PMID 35483361, Free PMC Article
  5. Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Inada H, et al. Genetics, 2006 Apr. PMID 16415369, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Guanylate cyclase
NP_001348700.1
  • Confirmed by transcript evidence
NP_001348701.1
  • Confirmed by transcript evidence
NP_001348702.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    3250975..3259354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001361853.3 → NP_001348700.1  Guanylate cyclase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16544
    UniProtKB/TrEMBL
    A0A2K5ATP8
    Conserved Domains (3) summary
    cd06352
    Location:45 → 461
    PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
    smart00044
    Location:870 → 1059
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cl21453
    Location:565 → 835
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001361852.3 → NP_001348701.1  Guanylate cyclase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16544
    UniProtKB/TrEMBL
    A0A2K5ATR8
    Conserved Domains (3) summary
    cd06352
    Location:45 → 456
    PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
    smart00044
    Location:865 → 1054
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cl21453
    Location:560 → 830
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001361854.3 → NP_001348702.1  Guanylate cyclase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16544
    UniProtKB/TrEMBL
    A0A2K5ATQ4
    Conserved Domains (3) summary
    cd06352
    Location:45 → 467
    PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
    smart00044
    Location:876 → 1065
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cl21453
    Location:571 → 841
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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