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gcy-37 Soluble guanylate cyclase gcy-37 [ Caenorhabditis elegans ]

Gene ID: 191658, updated on 2-Nov-2024

Summary

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Official Symbol
gcy-37
Official Full Name
Soluble guanylate cyclase gcy-37
Primary source
WormBase:WBGene00001557
Locus tag
CELE_C54E4.3
See related
AllianceGenome:WB:WBGene00001557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanylate cyclase activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to be located in cytoplasm. Predicted to be part of guanylate cyclase complex, soluble. Is expressed in AQR; PQR; URXL; and URXR. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gcy-37 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
16
Sequence:
Chromosome: IV; NC_003282.8 (2150647..2159169, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Thyroglobulin type-1 domain-containing protein Neighboring gene Secreted protein Neighboring gene Inositol oxygenase Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Soluble guanylyl cyclases in Caenorhabditis elegans: NO is not the answer. Morton DB, et al. Curr Biol, 1999 Jul 29-Aug 12. PMID 10469574
  2. Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Zimmer M, et al. Neuron, 2009 Mar 26. PMID 19323996, Free PMC Article
  3. Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Gray JM, et al. Nature, 2004 Jul 15. PMID 15220933
  4. Soluble guanylate cyclases act in neurons exposed to the body fluid to promote C. elegans aggregation behavior. Cheung BH, et al. Curr Biol, 2004 Jun 22. PMID 15203005
  5. The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior. Qin H, et al. Dev Biol, 2006 Oct 15. PMID 16919260

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxygen levels IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Soluble guanylate cyclase gcy-37
NP_500171.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2150647..2159169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067770.5 → NP_500171.2  Soluble guanylate cyclase gcy-37 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500171.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44468, Q65CM4, Q6DNF3
    Conserved Domains (4) summary
    smart00044
    Location:400 → 577
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam07700
    Location:3 → 165
    HNOB; Haem-NO-binding
    pfam07701
    Location:223 → 419
    HNOBA; Heme NO binding associated
    cl11967
    Location:425 → 609
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DNF3.1

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