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ins-5 Putative insulin-like peptide beta-type 6 [ Caenorhabditis elegans ]

Gene ID: 191686, updated on 2-Nov-2024

Summary

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Official Symbol
ins-5
Official Full Name
Putative insulin-like peptide beta-type 6
Primary source
WormBase:WBGene00002088
Locus tag
CELE_ZK84.3
See related
AllianceGenome:WB:WBGene00002088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hormone activity. Involved in dauer larval development. Predicted to be located in extracellular region. Is expressed in several structures, including coelomocyte; head muscle; neurons; somatic nervous system; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ins-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (5997557..5999022)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative insulin-like peptide beta-type 3 Neighboring gene putative insulin-like peptide beta-type 1 Neighboring gene putative insulin-like peptide beta-type 5 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. Segref A, et al. Nat Commun, 2022 Oct 5. PMID 36198694, Free PMC Article
  2. Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest. Chen Y, et al. Dev Biol, 2014 Oct 15. PMID 25128585
  3. Interaction between the ins/IGF-1 and p38 MAPK signaling pathways in molecular compensation of sod genes and modulation related to intracellular ROS levels in C. elegans. Yanase S, et al. Biochem Biophys Rep, 2020 Sep. PMID 32875124, Free PMC Article
  4. Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. Hung WL, et al. EMBO J, 2013 Jun 12. PMID 23665919, Free PMC Article
  5. Transcriptional profile of aging in C. elegans. Lund J, et al. Curr Biol, 2002 Sep 17. PMID 12372248

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Putative insulin-like peptide beta-type 6
NP_001380038.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5997557..5999022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393089.1 → NP_001380038.1  Putative insulin-like peptide beta-type 6 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P56173
    Conserved Domains (1) summary
    pfam03488
    Location:51 → 98
    Ins_beta; Nematode insulin-related peptide beta type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56173.2

Gene LinkOut

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