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irk-2 Inward rectifier potassium channel irk-1 [ Caenorhabditis elegans ]

Gene ID: 191695, updated on 2-Nov-2024

Summary

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Official Symbol
irk-2
Official Full Name
Inward rectifier potassium channel irk-1
Primary source
WormBase:WBGene00002150
Locus tag
CELE_M02A10.2
See related
AllianceGenome:WB:WBGene00002150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in intestine; pharyngeal-intestinal valve cell; spermatheca; and uterus. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; glucose metabolism disease (multiple); heart conduction disease (multiple); heroin dependence; and long QT syndrome (multiple). Orthologous to several human genes including KCNJ12 (potassium inwardly rectifying channel subfamily J member 12); KCNJ18 (potassium inwardly rectifying channel subfamily J member 18); and KCNJ2 (potassium inwardly rectifying channel subfamily J member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See irk-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
16
Sequence:
Chromosome: X; NC_003284.9 (702971..714498, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene NCAM (neural cell adhesion molecule) homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene E3 ubiquitin-protein ligase CBL Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reduced Ca(2+) transient amplitudes may signify increased or decreased depolarization depending on the neuromodulatory signaling pathway. Debnath A, et al. Front Neurosci, 2022. PMID 35937887, Free PMC Article
  2. The Na(+)-K(+)-ATPase is needed in glia of touch receptors for responses to touch in C. elegans. Johnson CK, et al. J Neurophysiol, 2020 May 1. PMID 32292107, Free PMC Article
  3. A new gene-finding tool: using the Caenorhabditis elegans operons for identifying functional partner proteins in human cells. Eichmüller S, et al. J Biol Chem, 2004 Feb 20. PMID 14615488
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Inward rectifier potassium channel irk-1
NP_001256976.2
  • Confirmed by transcript evidence
NP_001256977.1
  • Confirmed by transcript evidence
NP_001294850.1
  • Confirmed by transcript evidence
NP_001317907.1
  • Confirmed by transcript evidence
NP_001368348.1
  • Confirmed by transcript evidence
NP_001368610.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    702971..714498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380896.1 → NP_001368348.1  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PN13
    Conserved Domains (2) summary
    pfam01007
    Location:33 → 173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:180 → 354
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. NM_001270047.4 → NP_001256976.2  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256976.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YT08
    Conserved Domains (1) summary
    pfam01007
    Location:33 → 355
    IRK; Inward rectifier potassium channel

  3. NM_001330888.3 → NP_001317907.1  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1C3NSR3

  4. NM_001380895.1 → NP_001368610.1  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1C3NSN6
    Conserved Domains (2) summary
    pfam01007
    Location:66 → 206
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:213 → 387
    IRK_C; Inward rectifier potassium channel C-terminal domain

  5. NM_001307921.4 → NP_001294850.1  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294850.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PSB4
    Conserved Domains (1) summary
    pfam01007
    Location:33 → 355
    IRK; Inward rectifier potassium channel

  6. NM_001270048.3 → NP_001256977.1  Inward rectifier potassium channel irk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256977.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYE6
    Conserved Domains (1) summary
    pfam01007
    Location:33 → 355
    IRK; Inward rectifier potassium channel
Nucleotide Protein
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